Rictor mediates p53 deactivation to facilitate the malignant transformation of hepatocytes and promote hepatocarcinogenesis.

ABSTRACT:

Background

Mutations in TP53 gene is considered a main driver of hepatocellular carcinoma (HCC). While TP53 mutations are the leading cause of p53 dysfunction, their occurrence rates may drop to approximately 10% in cohorts without hepatitis B virus and aflatoxin exposure. This observation suggests that the deactivation of wild-type p53 (p53^wt) may be a critical factor in the majority of HCC cases. However, the mechanism undermining p53^wt activity in the liver remains unclear.

Methods

Microarray analysis and luciferase assay were utilized to confirm target associations. Gain- and/or loss-of-function methods were employed to assess alterations in signaling pathways. Protein interactions were analyzed by molecular immunological methods and further visuali

SUBMITTER: Wang C 

PROVIDER: S-EPMC10729423 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature