A combined analysis of multi-omics data reveals the prognostic values and immunotherapy response of LAG3 in human cancers.

ABSTRACT: Lymphocyte-activation gene 3 (LAG3) is a highly anticipated immune checkpoint in the context of cancer, exerting regulatory control over immune cell proliferation and function to reinforce the advancement of cancers. However, the comprehensive functional analysis of LAG3 across various cancer types remains undisclosed; thus, this study aims to investigate the pan-cancer expression profile of LAG3. We have investigated the expression profile, prognostic significance, and genetic alterations of LAG3 in various cancers while elucidating its characteristic in immune response regulation. Our findings demonstrated that elevated LAG3 expression is significantly associated with favorable prognosis in patients with cutaneous melanoma (SKCM), and it may be a potential biomarker for SKCM. Furthermore

SUBMITTER: Peng J 

PROVIDER: S-EPMC10729452 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature