Effects of physical activity and sedentary time on depression, anxiety and well-being: a bidirectional Mendelian randomisation study.

ABSTRACT:

Background

Mental health conditions represent one of the major groups of non-transmissible diseases. Physical activity (PA) and sedentary time (ST) have been shown to affect mental health outcomes in opposite directions. In this study, we use accelerometery-derived measures of PA and ST from the UK Biobank (UKB) and depression, anxiety and well-being data from the UKB mental health questionnaire as well as published summary statistics to explore the causal associations between these phenotypes.

Methods

We used MRlap to test if objectively measured PA and ST associate with mental health outcomes using UKB data and summary statistics from published genome-wide association studies. We also tested for bidirectional associations. We performed sex stratified as well as sensitivity

SUBMITTER: Casanova F 

PROVIDER: S-EPMC10729457 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature