Amyloid-β specific regulatory T cells attenuate Alzheimer's disease pathobiology in APP/PS1 mice.

ABSTRACT:

Background

Regulatory T cells (Tregs) maintain immune tolerance. While Treg-mediated neuroprotective activities are now well-accepted, the lack of defined antigen specificity limits their therapeutic potential. This is notable for neurodegenerative diseases where cell access to injured brain regions is required for disease-specific therapeutic targeting and improved outcomes. To address this need, amyloid-beta (Aβ) antigen specificity was conferred to Treg responses by engineering the T cell receptor (TCR) specific for Aβ (TCR_Aβ). The TCR_Ab were developed from disease-specific T cell effector (Teff) clones. The ability of Tregs expressing a transgenic TCR_Aβ (TCR_Aβ -Tregs) to reduce Aβ burden, transform effector to regulatory ce

SUBMITTER: Yeapuri P 

PROVIDER: S-EPMC10729469 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature