Evaluation of noninvasive biospecimens for transcriptome studies.

ABSTRACT: Transcriptome studies disentangle functional mechanisms of gene expression regulation and may elucidate the underlying biology of disease processes. However, the types of tissues currently collected typically assay a single post-mortem timepoint or are limited to investigating cell types found in blood. Noninvasive tissues may improve disease-relevant discovery by enabling more complex longitudinal study designs, by capturing different and potentially more applicable cell types, and by increasing sample sizes due to reduced collection costs and possible higher enrollment from vulnerable populations. Here, we develop methods for sampling noninvasive biospecimens, investigate their performance across commercial and in-house library preparations, characterize their biology, and assess the fea

SUBMITTER: Martorella M 

PROVIDER: S-EPMC10729488 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature