Oxygen therapy attenuates neuroinflammation after spinal cord injury.

ABSTRACT: Acute hyperbaric O₂ (HBO) therapy after spinal cord injury (SCI) can reduce inflammation and increase neuronal survival. To our knowledge, it is unknown if these benefits of HBO require hyperbaric vs. normobaric hyperoxia. We used a C4 lateralized contusion SCI in adult male and female rats to test the hypothesis that the combination of hyperbaria and 100% O₂ (i.e. HBO) more effectively mitigates spinal inflammation and neuronal loss, and enhances respiratory recovery, as compared to normobaric 100% O₂. Experimental groups included spinal intact, SCI no O₂ therapy, and SCI + 100% O₂ delivered at normobaric pressure (1 atmosphere, ATA), or at 2- or 3 ATA. O₂ treatments lasted 1-h, commenced within 2-h of SCI, and were repeate

SUBMITTER: Sunshine MD 

PROVIDER: S-EPMC10729514 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature