Pain and itch coding mechanisms of polymodal sensory neurons.

ABSTRACT: Pain and itch coding mechanisms in polymodal sensory neurons remain elusive. MrgprD⁺ neurons represent a major polymodal population and mediate both mechanical pain and nonhistaminergic itch. Here, we show that chemogenetic activation of MrgprD⁺ neurons elicited both pain- and itch-related behavior in a dose-dependent manner, revealing an unanticipated compatibility between pain and itch in polymodal neurons. While VGlut2-dependent glutamate release is required for both pain and itch transmission from MrgprD⁺ neurons, the neuropeptide neuromedin B (NMB) is selectively required for itch signaling. Electrophysiological recordings further demonstrated that glutamate synergizes with NMB to excite NMB-sensitive postsynaptic neurons. Ablation of these spinal neur

SUBMITTER: Guo C 

PROVIDER: S-EPMC10729537 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature