Apoptosis-resistant megakaryocytes produce large and hyperreactive platelets in response to radiation injury.

ABSTRACT:

Background

The essential roles of platelets in thrombosis have been well recognized. Unexpectedly, thrombosis is prevalent during thrombocytopenia induced by cytotoxicity of biological, physical and chemical origins, which could be suffered by military personnel and civilians during chemical, biological, radioactive, and nuclear events. Especially, thrombosis is considered a major cause of mortality from radiation injury-induced thrombocytopenia, while the underlying pathogenic mechanism remains elusive.

Methods

A mouse model of radiation injury-induced thrombocytopenia was built by exposing mice to a sublethal dose of ionizing radiation (IR). The phenotypic and functional changes of platelets and megakaryocytes (MKs) were determined by a comprehensive set of in vitro and in

SUBMITTER: Du CH 

PROVIDER: S-EPMC10729570 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature