Immune and oxidative stress disorder in ovulation-dysfunction women revealed by single-cell transcriptome.

ABSTRACT:

Introduction

Ovulation dysfunction is now a widespread cause of infertility around the world. Although the impact of immune cells in human reproduction has been widely investigated, systematic understanding of the changes of the immune atlas under female ovulation remain less understood.

Methods

Here, we generated single cell transcriptomic profiles of 80,689 PBMCs in three representative statuses of ovulation dysfunction, i.e., polycystic ovary syndrome (PCOS), primary ovarian insufficiency (POI) and menopause (MENO), and identified totally 7 major cell types and 25 subsets of cells.

Results

Our study revealed distinct cluster distributions of immune cells among individuals of ovulation disorders and health. In patients with ovulation dysfunction, we observed a signi

SUBMITTER: Qi L 

PROVIDER: S-EPMC10729704 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature