T cell receptor sequences are the dominant factor contributing to the phenotype of CD8⁺ T cells with specificities against immunogenic viral antigens.

ABSTRACT: Antigen-specific CD8⁺ T cells mediate pathogen clearance. T cell phenotype is influenced by T cell receptor (TCR) sequences and environmental signals. Quantitative comparisons of these factors in human disease, while challenging to obtain, can provide foundational insights into basic T cell biology. Here, we investigate the phenotype kinetics of 679 CD8⁺ T cell clonotypes, each with specificity against one of three immunogenic viral antigens. Data were collected from a longitudinal study of 68 COVID-19 patients with antigens from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), cytomegalovirus (CMV), and influenza. Each antigen is associated with a different type of immune activation during COVID-19. We find TCR sequence to be by far the most important fa

SUBMITTER: Chen DG 

PROVIDER: S-EPMC10729740 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature