Modeling seeding and neuroanatomic spread of pathology in amyotrophic lateral sclerosis.

ABSTRACT: The neurodegenerative disorder amyotrophic lateral sclerosis (ALS) is characterized by the progressive loss of upper and lower motor neurons, with pathological involvement of cerebral motor and extra-motor areas in a clinicopathological spectrum with frontotemporal dementia (FTD). A key unresolved issue is how the non-random distribution of pathology in ALS reflects differential network vulnerability, including molecular factors such as regional gene expression, or preferential spread of pathology via anatomical connections. A system of histopathological staging of ALS based on the regional burden of TDP-43 pathology observed in postmortem brains has been supported to some extent by analysis of distribution of in vivo structural MRI changes. In this paper, computational modeling using a Ne

SUBMITTER: Pandya S 

PROVIDER: S-EPMC10729776 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature