Interplay between the plasma membrane and cell-cell adhesion maintains epithelial identity for correct polarised cell divisions.

ABSTRACT: Polarised epithelial cell divisions represent a fundamental mechanism for tissue maintenance and morphogenesis. Morphological and mechanical changes in the plasma membrane influence the organisation and crosstalk of microtubules and actin at the cell cortex, thereby regulating the mitotic spindle machinery and chromosome segregation. Yet, the precise mechanisms linking plasma membrane remodelling to cell polarity and cortical cytoskeleton dynamics to ensure accurate execution of mitosis in mammalian epithelial cells remain poorly understood. Here, we manipulated the density of mammary epithelial cells in culture, which led to several mitotic defects. Perturbation of cell-cell adhesion formation impairs the dynamics of the plasma membrane, affecting the shape and size of mitotic cells and r

SUBMITTER: Hosawi MM 

PROVIDER: S-EPMC10729819 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature