Displacement of the Lamina Cribrosa With Acute Intraocular Pressure Increase in Brain-Dead Organ Donors.

ABSTRACT:

Purpose

To examine deformations of the optic nerve head (ONH) deep tissues in response to acute elevation of intraocular pressure (IOP).

Methods

Research-consented brain-dead organ donors underwent imaging by spectral domain optical coherence tomography (OCT). OCT imaging was repeated while the eye was sequentially maintained at manometric pressures of 10, 30, and 50 mm Hg. Radial scans of the ONH were automatically segmented by deep learning and quantified in three dimensions by a custom algorithm. Change in lamina cribrosa (LC) depth and choroidal thickness was correlated with IOP and age by linear mixed-effect models. LC depth was computed against commonly utilized reference planes.

Results

Twenty-six eyes from 20 brain-dead organ donors (age range, 22-62 years; me

SUBMITTER: Girkin CA 

PROVIDER: S-EPMC10729839 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature