Association Between Renal Sinus Fat and Cardiometabolic and Renin-Angiotensin System Parameters in Primary Aldosteronism.

ABSTRACT:

Context

Renal sinus fat (RSF) accumulation is associated with cardiometabolic diseases, such as obesity, diabetes, hypertension, and chronic kidney disease. However, clinical implications of RSF in primary aldosteronism (PA) remain unclear.

Objective

We aimed to investigate relationships between RSF volume and key cardiometabolic and renin-angiotensin system (RAS) parameters in PA patients and clarify the differences in these relationships between unilateral and bilateral subtypes.

Methods

We analyzed data obtained from well-characterized PA patients that involved 45 unilateral (median age: 52 years; 42.2% men) and 92 bilateral patients (51 years; 42.4% men).

Results

RSF volume normalized by renal volume (RSF%) was greater in the unilateral group than in the bi

SUBMITTER: Mitsuno R 

PROVIDER: S-EPMC10729860 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature