Menopausal hormone therapy and central nervous system tumors: Danish nested case-control study.

ABSTRACT:

Background

Use of estrogen-containing menopausal hormone therapy has been shown to influence the risk of central nervous system (CNS) tumors. However, it is unknown how the progestin-component affects the risk and whether continuous versus cyclic treatment regimens influence the risk differently.

Methods and findings

Nested case-control studies within a nationwide cohort of Danish women followed for 19 years from 2000 to 2018. The cohort comprised 789,901 women aged 50 to 60 years during follow-up, without prior CNS tumor diagnosis, cancer, or contraindication for treatment with menopausal hormone therapy. Information on cumulative exposure to female hormonal drugs was based on filled prescriptions. Statistical analysis included educational level, use of antihistamines, and

SUBMITTER: Pourhadi N 

PROVIDER: S-EPMC10729984 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature