Motoneuron-driven computational muscle modelling with motor unit resolution and subject-specific musculoskeletal anatomy.

ABSTRACT: The computational simulation of human voluntary muscle contraction is possible with EMG-driven Hill-type models of whole muscles. Despite impactful applications in numerous fields, the neuromechanical information and the physiological accuracy such models provide remain limited because of multiscale simplifications that limit comprehensive description of muscle internal dynamics during contraction. We addressed this limitation by developing a novel motoneuron-driven neuromuscular model, that describes the force-generating dynamics of a population of individual motor units, each of which was described with a Hill-type actuator and controlled by a dedicated experimentally derived motoneuronal control. In forward simulation of human voluntary muscle contraction, the model transforms a vector

SUBMITTER: Caillet AH 

PROVIDER: S-EPMC10729998 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature