Enduring effects of early-life adversity on reward processes: A systematic review and meta-analysis of animal studies.

ABSTRACT: Two-thirds of individuals experience adversity during childhood such as neglect, abuse or highly-stressful events. Early-life adversity (ELA) increases the life-long risk of developing mood and substance use disorders. Reward-related deficits has emerged as a key endophenotype of such psychiatric disorders. Animal models are invaluable for studying how ELA leads to reward deficits. However, the existing literature is heterogenous with difficult to reconcile findings. To create an overview, we conducted a systematic review containing multiple meta-analyses regarding the effects of ELA on reward processes overall and on specific aspects of reward processing in animal models. A comprehensive search identified 120 studies. Most studies omitted key details resulting in unclear risk of bias. Ove

SUBMITTER: Duque-Quintero M 

PROVIDER: S-EPMC10729999 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature