Cesarean section induced dysbiosis promotes type 2 immunity but not oxazolone-induced dermatitis in mice.

ABSTRACT: Delivery by cesarean section (CS) is associated with an altered gut microbiota (GM) colonization and a higher risk of later chronic inflammatory diseases. Studies investigating the association between CS and atopic dermatitis (AD) are contradictive and often biased by confounding factors. The aim of this study was therefore to provide experimental evidence for the association between CS and AD in a mouse model and clarify the role of the GM changes associated with CS. It was hypothesized that CS-delivered mice, and human CS-GM transplanted mice develop severe dermatitis due to early dysbiosis. BALB/c mice delivered by CS or vaginally (VD) as well as BALB/c mice transplanted with GM from CS or VD human donors were challenged with oxazolone on the ear. The severity of dermatitis was evaluate

SUBMITTER: Zachariassen LF 

PROVIDER: S-EPMC10730161 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature