Diet-induced shifts in the gut microbiota influence anastomotic healing in a murine model of colonic surgery.

ABSTRACT: Host diet and gut microbiota interact to contribute to perioperative complications, including anastomotic leak (AL). Using a murine surgical model of colonic anastomosis, we investigated how diet and fecal microbial transplantation (FMT) impacted the intestinal microbiota and if a predictive signature for AL could be determined. We hypothesized that a Western diet (WD) would impact gut microbial composition and that the resulting dysbiosis would correlate with increased rates of AL, while FMT from healthy, lean diet (LD) donors would reduce the risk of AL. Furthermore, we predicted that surgical outcomes would allow for the development of a microbial preclinical translational tool to identify AL. Here, we show that AL is associated with a dysbiotic microbial community characterized by incr

SUBMITTER: Boatman S 

PROVIDER: S-EPMC10730186 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature