Heterogeneous associations of gut microbiota with Crohn's disease activity.

ABSTRACT: The multi-factorial involvement of gut microbiota with Crohn's disease (CD) necessitates robust analysis to uncover possible associations with particular microbes. CD has been linked to specific bacteria, but reported associations vary widely across studies. This inconsistency may result from heterogeneous associations across individual patients, resulting in no apparent or only weak relationships with the means of bacterial abundances. We investigated the relationship between bacterial relative abundances and disease activity in a longitudinal cohort of CD patients (n = 57) and healthy controls (n = 15). We applied quantile regression, a statistical technique that allows investigation of possible relationships outside the mean response. We found several significant and mostl

SUBMITTER: Pinto S 

PROVIDER: S-EPMC10730216 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature