Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice.

ABSTRACT: The development of single-molecule co-agonists for the glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) is considered a breakthrough in the treatment of obesity and type 2 diabetes. But although GIPR-GLP-1R co-agonism decreases body weight with superior efficacy relative to GLP-1R agonism alone in preclinical^1-3 and clinical studies^4,5, the role of GIP in regulating energy metabolism remains enigmatic. Increasing evidence suggests that long-acting GIPR agonists act in the brain to decrease body weight through the inhibition of food intake^3,6-8; however, the mechanisms and neuronal populations through which GIP affects metabolism remain to be identified. Here, we report that long-acting

SUBMITTER: Liskiewicz A 

PROVIDER: S-EPMC10730394 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature