Neuronal TIMP2 regulates hippocampus-dependent plasticity and extracellular matrix complexity.

ABSTRACT: Functional output of the hippocampus, a brain region subserving memory function, depends on highly orchestrated cellular and molecular processes that regulate synaptic plasticity throughout life. The structural requirements of such plasticity and molecular events involved in this regulation are poorly understood. Specific molecules, including tissue inhibitor of metalloproteinases-2 (TIMP2) have been implicated in plasticity processes in the hippocampus, a role that decreases with brain aging as expression is lost. Here, we report that TIMP2 is highly expressed by neurons within the hippocampus and its loss drives changes in cellular programs related to adult neurogenesis and dendritic spine turnover with corresponding impairments in hippocampus-dependent memory. Consistent with the accumu

SUBMITTER: Ferreira AC 

PROVIDER: S-EPMC10730400 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature