Maternal oxidative stress during pregnancy associated with emotional and behavioural problems in early childhood: implications for foetal programming.

ABSTRACT: Childhood mental disorders, including emotional and behavioural problems (EBP) are increasingly prevalent. Higher maternal oxidative stress (OS) during pregnancy (_matOS_preg) is linked to offspring mental disorders. Environmental factors contribute to _matOS_preg. However, the role of _matOS_preg in childhood EBP is unclear. We investigated the associations between (i) _matOS_preg and offspring EBP; (ii) social and prenatal environmental factors and _matOS_preg; and (iii) social and prenatal factors and childhood EBP and evaluated whether _matOS_preg mediated these associations. Maternal urinary OS biomarkers, 8-hydroxyguanosine (8-OHGua; an oxidative RNA damage marker)

SUBMITTER: Pham C 

PROVIDER: S-EPMC10730421 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature