Gut microbiota and risk of polycystic ovary syndrome: Insights from Mendelian randomization.

ABSTRACT:

Background

Polycystic ovary syndrome (PCOS) is a multifaceted endocrine and metabolic syndrome with complex origins and pathogenesis that has not yet been fully elucidated. Recently, the interconnection between gut microbiota and metabolic diseases has gained prominence in research, generating new insights into the correlation between PCOS and gut microbiota composition. However, the causal link between PCOS and gut microbiota remains relatively unexplored, indicating a crucial gap in current research.

Methods

We conducted a two-sample Mendelian randomization analysis using summary statistics obtained from the MiBioGen Consortium's extensive genome-wide association studies (GWAS) meta-analysis, focusing on the gut microbiota. Summary statistics for PCOS were acquired from th

SUBMITTER: Li JW 

PROVIDER: S-EPMC10730437 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature