Prognostic gene HLA-DMA associated with cell cycle and immune infiltrates in LUAD.

ABSTRACT:

Background

The dominant subclass of non-small-cell lung cancer (NSCLC) is lung adenocarcinoma (LUAD). The tumor microenvironment (TME) is a crucial feature of carcinogenesis and progression in LUAD. Furthermore, immune and stromal components of TME are crucial factors to investigating and curing LUAD. Thus, the study assessed the value of TME-related genes for LUAD prognosis and immune infiltration.

Methods

All data were downloaded from TCGA and GEO databases. The immune and stromal scores were downloaded from ESTIMATE, and the association between the scores and prognosis was explored by Kaplan-Meier survival analysis. Protein-protein interaction (PPI) network and univariate Cox regression were used to find TME-related differentially expressed genes (DEGs), and HLA-DMA was r

SUBMITTER: Huang YJ 

PROVIDER: S-EPMC10730455 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature