Protein-protein interaction network module changes associated with the vertebrate fin-to-limb transition.

ABSTRACT: Evolutionary phenotypic transitions, such as the fin-to-limb transition in vertebrates, result from modifications in related proteins and their interactions, often in response to changing environment. Identifying these alterations in protein networks is crucial for a more comprehensive understanding of these transitions. However, previous research has not attempted to compare protein-protein interaction (PPI) networks associated with evolutionary transitions, and most experimental studies concentrate on a limited set of proteins. Therefore, the goal of this work was to develop a network-based platform for investigating the fin-to-limb transition using PPI networks. Quality-enhanced protein networks, constructed by integrating PPI networks with anatomy ontology data, were leveraged to compa

SUBMITTER: Fernando PC 

PROVIDER: S-EPMC10730527 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature