Proteomic analysis reveals activation of platelet- and fibrosis-related pathways in hearts of ApoE^-/- mice exposed to diesel exhaust particles.

ABSTRACT: Air pollution is an environmental risk factor linked to multiple human diseases including cardiovascular diseases (CVDs). While particulate matter (PM) emitted by diesel exhaust damages multiple organ systems, heart disease is one of the most severe pathologies affected by PM. However, the in vivo effects of diesel exhaust particles (DEP) on the heart and the molecular mechanisms of DEP-induced heart dysfunction have not been investigated. In the current study, we attempted to identify the proteomic signatures of heart fibrosis caused by diesel exhaust particles (DEP) in CVDs-prone apolipoprotein E knockout (ApoE^-/-) mice model using tandem mass tag (TMT)-based quantitative proteomic analysis. DEP exposure induced mild heart fibrosis in ApoE^-/- mice compared with seve

SUBMITTER: Jung I 

PROVIDER: S-EPMC10730529 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature