Nucleus accumbens core single cell ensembles bidirectionally respond to experienced versus observed aversive events.

ABSTRACT: Fear learning is a critical feature of survival skills among mammals. In rodents, fear learning manifests itself through direct experience of the aversive event or social transmission of aversive stimuli such as observing and acting on conspecifics' distress. The neuronal network underlying the social transmission of information largely overlaps with the brain regions that mediate behavioral responses to aversive and rewarding stimuli. In this study, we recorded single cell activity patterns of nucleus accumbens (NAc) core neurons using in vivo optical imaging of calcium transients via miniature scopes. This cutting-edge imaging methodology not only allows us to record activity patterns of individual neurons but also lets us longitudinally follow these individual neurons across time and di

SUBMITTER: Dinckol O 

PROVIDER: S-EPMC10730531 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature