Identification of key genes modules linking diabetic retinopathy and circadian rhythm.

ABSTRACT:

Background

Diabetic retinopathy (DR) is a leading cause of vision loss worldwide. Recent studies highlighted the crucial impact of circadian rhythms (CR) on normal retinopathy in response to the external light cues. However, the role of circadian rhythms in DR pathogenesis and potential investigational drugs remains unclear.

Methods

To investigate the weather CR affects DR, differential expression analysis was employed to identify differentially expressed genes (DEGs) from the GEO database (GSE160306). Functional enrichment analysis was conducted to identify relevant signaling pathways. LASSO regression was utilized to screen pivotal genes. Weighted gene co-expression network anlaysis (WGCNA) was applied to identify different modules. Additionally, we use the Comparative Tox

SUBMITTER: Ling F 

PROVIDER: S-EPMC10730663 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature