Garlic consumption and colorectal cancer risk in US adults: a large prospective cohort study.

ABSTRACT:

Objective

To clarify the inconsistent findings of epidemiological studies on the association between dietary garlic consumption and colorectal cancer (CRC) incidence, by prospectively assessing the association in a large US population.

Methods

Data of 58,508 participants (aged 55-74) from the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial were analyzed. Dietary data were collected using a validated questionnaire. Multivariable Cox regression analysis determined hazard ratio (HR) and 95% confidence interval (CI). Restricted cubic spline regression was used to investigate the non-linear relationship, and subgroup analysis was conducted to examine potential effect modifiers.

Results

During a median follow-up of 12.05 years, 782 CRC cases were docum

SUBMITTER: Jiang Z 

PROVIDER: S-EPMC10730668 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature