Oxidative stress drives vascular smooth muscle cell damage in acute Stanford type A aortic dissection through HIF-1α/HO-1 mediated ferroptosis.

ABSTRACT:

Background

Acute Stanford type A aortic dissection (ATAAD) is characterized by intimal tearing and false lumen formation containing large amounts of erythrocytes with heme. Heme oxygenase 1 (HO-1) is the key enzyme to degrade heme for iron accumulation and further ferroptosis. The current study aimed at investigating the role of HO-1 in the dissection progression of ATAAD.

Methods

Bioinformatic analyses and experimental validation were performed to reveal ferroptosis and HO-1 expression in ATAAD. Human aortic vascular smooth muscle cell (HA-VSMC) was used to explore underlying molecular mechanisms and the role of HO-1 overexpression in ATAAD.

Results

Ferroptosis was identified as a critical manner of regulated cell death in ATAAD. HO-1 was screened as a key signature

SUBMITTER: Song W 

PROVIDER: S-EPMC10730757 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature