The urine-to-plasma urea concentration ratio is associated with eGFR and eGFR decline over time in a population cohort.

ABSTRACT:

Background

Evaluation of renal function and of factors associated with its decline are important public health issues. Besides markers of glomerular function [e.g. glomerular filtration rate (GFR)], those of tubular functions are rarely evaluated. Urea, the most abundant urinary solute, is markedly concentrated in urine when compared with plasma. We explored the urine-to-plasma ratio of urea concentrations (U/P urea ratio) as a marker of tubular functions.

Methods

We evaluated the relationship of the U/P urea ratio with eGFR at baseline in 1043 participants (48 ± 17 years) from the Swiss Kidney Project on Genes in Hypertension (SKIPOGH) population-based cohort, using mixed regression. In 898 participants, we assessed the relation between U/P urea ratio and renal function dec

SUBMITTER: Petrovic D 

PROVIDER: S-EPMC10730796 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature