Modulation of memory reconsolidation by adjacent novel tasks: timing defines the nature of change.

ABSTRACT: Reconsolidation turns memories into a responsive state that allows their modulation until they stabilize again. This phenomenon attracted remarkable attention due to its potential impact on therapeutics and education. Recent evidence revealed that different memories undergo reconsolidation via a behavioral tagging process. Thus, their re-stabilization involves setting "reconsolidation-tags" and synthesizing plasticity-related proteins for their capture at the tagged sites. Here, we studied the possibility of affecting these fundamental mechanisms to modulate reconsolidation. Our findings, in laboratory rats, indicate that exploring a novel environment 60 min before or after memory reactivation improves spatial object recognition memory by promoting protein synthesis. Conversely, experienci

SUBMITTER: Schroeder MN 

PROVIDER: S-EPMC10730840 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature