Time-of-day-dependent variation of the human liver transcriptome and metabolome is disrupted in MASLD.

ABSTRACT:

Background & aims

Liver homeostasis is ensured in part by time-of-day-dependent processes, many of them being paced by the molecular circadian clock. Liver functions are compromised in metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH), and clock disruption increases susceptibility to MASLD progression in rodent models. We therefore investigated whether the time-of-day-dependent transcriptome and metabolome are significantly altered in human steatotic and MASH livers.

Methods

Liver biopsies, collected within an 8 h-window from a carefully phenotyped cohort of 290 patients and histologically diagnosed to be either normal, steatotic or MASH hepatic tissues, were analyzed by RNA sequencing and unbiased me

SUBMITTER: Johanns M 

PROVIDER: S-EPMC10730870 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature