Mendelian randomization study reveals the relationship between dietary factors and respiratory diseases.

ABSTRACT: The existence of causal relationship between dietary factors and respiratory diseases is uncertain. We comprehensively investigated the association between dietary factors and respiratory diseases by using Mendelian randomization (MR). Genetic variants linked to dietary factors were selected as instrumental variables with genome-wide significance. These instrumental variables were obtained from large GWAS databases. These databases include Biobank, the FinnGen study, and other large consortia. We used multivariate MR analyses to control the effects of smoking and education. Median analysis was conducted to evaluate whether body mass index (BMI) played a role in dietary factors in respiratory diseases. Dried fruit intake was found to be associated with a decreased risk of chronic obstructiv

SUBMITTER: Lai W 

PROVIDER: S-EPMC10730871 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature