Synaptic density affects clinical severity via network dysfunction in syndromes associated with frontotemporal lobar degeneration.

ABSTRACT: There is extensive synaptic loss from frontotemporal lobar degeneration, in preclinical models and human in vivo and post mortem studies. Understanding the consequences of synaptic loss for network function is important to support translational models and guide future therapeutic strategies. To examine this relationship, we recruited 55 participants with syndromes associated with frontotemporal lobar degeneration and 24 healthy controls. We measured synaptic density with positron emission tomography using the radioligand [¹¹C]UCB-J, which binds to the presynaptic vesicle glycoprotein SV2A, neurite dispersion with diffusion magnetic resonance imaging, and network function with task-free magnetic resonance imaging functional connectivity. Synaptic density and neurite dispersion in

SUBMITTER: Whiteside DJ 

PROVIDER: S-EPMC10730886 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature