Influence of genomic variations on glanders serodiagnostic antigens using integrative genomic and transcriptomic approaches.

ABSTRACT: Glanders is a highly contagious and life-threatening zoonotic disease caused by Burkholderia mallei (B. mallei). Without an effective vaccine or treatment, early diagnosis has been regarded as the most effective method to prevent glanders transmission. Currently, the diagnosis of glanders is heavily reliant on serological tests. However, given that markedly different host immune responses can be elicited by genetically different strains of the same bacterial species, infection by B. mallei, whose genome is unstable and plastic, may result in various immune responses. This variability can make the serodiagnosis of glanders challenging. Therefore, there is a need for a comprehensive understanding and assessment of how B. mallei genomic variations impact the approp

SUBMITTER: Charron P 

PROVIDER: S-EPMC10730941 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature