Sutterella and its metabolic pathways positively correlate with vaccine-elicited antibody responses in infant rhesus macaques.

ABSTRACT:

Introduction

It is becoming clearer that the microbiota helps drive responses to vaccines; however, little is known about the underlying mechanism. In this study, we aimed to identify microbial features that are associated with vaccine immunogenicity in infant rhesus macaques.

Methods

We analyzed 16S rRNA gene sequencing data of 215 fecal samples collected at multiple timepoints from 64 nursery-reared infant macaques that received various HIV vaccine regimens. PERMANOVA tests were performed to determine factors affecting composition of the gut microbiota throughout the first eight months of life in these monkeys. We used DESeq2 to identify differentially abundant bacterial taxa, PICRUSt2 to impute metagenomic information, and mass spectrophotometry to determine levels of fec

SUBMITTER: Jiang D 

PROVIDER: S-EPMC10731017 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature