The gut microbiome and metabolites are altered and interrelated in patients with functional constipation.

ABSTRACT:

Introduction

Gut microbiota and metabolites have been identified to contribute to the pathogenesis of functional constipation (FC); however, the underlying mechanism(s) have not been elucidated, and the relationship between the gut microbiota and metabolites in FC has received limited attention in the literature.

Methods

16S rDNA sequencing and non-targeted metabolomic detection based on liquid chromatography-mass spectrometry (LC-MS/MS) technologies were combined to analyze the altered gut microbiome and metabolic profile of fecal samples from FC patients and healthy individuals (healthy control; HC).

Results

The richness and diversity of gut microbiota significantly (p < 0.01) increased in FC patients. Compared to the HC group, 18 genera, including Intesti

SUBMITTER: Li YQ 

PROVIDER: S-EPMC10731029 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature