Development and testing of a transcatheter heart valve with reduced calcification potential.

ABSTRACT:

Introduction

Patients from developing countries who require heart valve surgery are younger and have less access to open heart surgery than those from developed countries. Transcatheter heart valves (THVs) may be an alternative but are currently unsuitable for young patients because of their inadequate durability. We developed and tested a THV utilizing two new types of decellularized bovine pericardial leaflets in an ovine model.

Methods

The two decellularized tissues [one with a very low dose (0.05%) of monomeric glutaraldehyde (GA) fixation and detoxification (DF) and the other without glutaraldehyde (DE)] were compared to an industry standard [Glycar-fixed with the standard dose (0.625%) of glutaraldehyde]. THVs were manufactured with the three tissue types and implanted

SUBMITTER: Weich H 

PROVIDER: S-EPMC10731034 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature