A multi-spectroscopic and molecular docking approach for DNA/protein binding study and cell viability assay of first-time reported pendent azide bearing Cu(II)-quercetin and dicyanamide bearing Zn(II)-quercetin complexes.

ABSTRACT: In the current study, one new quercetin-based Zn(II) complex [Zn(Qr)(CNNCN)(H₂O)₂] (Complex 1) which is developed by condensation of quercetin with ZnCl₂ in the presence of NaN(CN)₂ and Cu(II) complex [Cu(Qr)N₃(CH₃OH)(H₂O)] (complex 2) which is developed by the condensation reaction of quercetin and CuCl₂ in presence of NaN_3, are thoroughly examined in relation to their use in biomedicine. The results of several spectroscopic studied confirm the structure of both the complexes and the Density Functional Theory (DFT) study helps to optimize the structure of complex 1 and 2. After completion of the identification process, DNA and Human Serum Albumin (HSA) binding efficacy of both

SUBMITTER: Mudi A 

PROVIDER: S-EPMC10731082 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature