A randomized controlled trial comparing blood pressure reduction in hyperacute phase of spontaneous intracerebral hemorrhage by continuous nicardipine infusion with or without a preceding nicardipine bolus dose.

ABSTRACT:

Objectives

To determine whether addition of an intravenous bolus dose before continuous nicardipine infusion would improve blood pressure reduction in the hyperacute phase in patients with spontaneous intracerebral hemorrhage (ICH).

Design

Double-blind randomized controlled trial.

Setting

One academic emergency department (ED) in Bangkok, Thailand.

Participants

Adult patients with spontaneous ICH presented to the ED between June 30, 2022, and July 15, 2023.

Interventions

The bolus group (n = 31) received an intravenous bolus dose of nicardipine before nicardipine continuous infusion, whereas the non-bolus group (n = 31) was given a placebo and nicardipine continuous infusion.

Main outcomes

Systolic blood pressure (SBP) within the first hour (being

SUBMITTER: Nithimathachoke A 

PROVIDER: S-EPMC10731089 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature