Genomic epidemiology reveals early transmission of SARS-CoV-2 and mutational dynamics in Nanning, China.

ABSTRACT: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants are a fatal pathogen resulting in substantial morbidity and mortality, and posing a great threat to human health with epidemics and pandemics.

Methods

Next-generation sequencing (NGS) was performed to investigate the SARS-CoV-2 genomic characterization. Phylogenetic analysis of SARS-CoV-2 genomes was used to probe the evolutionary. Homology protein structure modelling was done to explore potential effect of the mutations.

Results

The eighty genome sequences of SARS-CoV-2 obtained from the thirty-nine patients with COVID-19. A novel variant with mutation H625R concomitant with S50L in spike glycoprotein had been identified. Phylogenetic analysis revealed that SARS-CoV-2 variants belong to several distinct li

SUBMITTER: Bi D 

PROVIDER: S-EPMC10731232 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature