Salivary signatures of oral-brain communication in sleep bruxers.

ABSTRACT:

Introduction

Microbiota and their interaction with hosts have been of great interest in brain research in recent years. However, the role of oral microbiota in mental illness and the underlying mechanism of oral-brain communication remains elusive. Sleep bruxism (SB) is an oral parafunctional activity related to the nervous system and is considered a risk factor for harmful clinical consequences and severe systemic conditions. Exploring the connection between oral microbiota and sleep bruxism may deepen our understanding of the complex relationship between oral-brain axis and provide insights for treatment.

Methods

In this study, salivary samples were collected from 22 individuals with SB and 21 healthy controls, and metagenomics with metabolomics was performed. Nonparametri

SUBMITTER: Deng Y 

PROVIDER: S-EPMC10731308 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature