Low OGDHL expression affects the prognosis and immune infiltration of kidney renal clear cell carcinoma.

ABSTRACT:

Background

Oxoglutarate dehydrogenase-like (OGDHL) modulates glutamine metabolism to influence tumor progression. Therefore, we aimed to explore the potential role of OGDHL in the prognosis of kidney renal clear cell carcinoma (KIRC) and its effect on immune infiltration.

Methods

The Cancer Genome Atlas, Tumor Immune Estimation Resource, Gene Expression Profiling Interactive Analysis, Human Protein Atlas, and The University of Alabama at Birmingham Cancer databases and the GSE53757 dataset were utilized to analyze expression difference and prognosis of OGDHL in tumor and normal tissue; diagnostic value was assessed using receiver operating characteristic curves. Correlations with clinical features and survival prognosis were analyzed. Independent prognos

SUBMITTER: Xie Z 

PROVIDER: S-EPMC10731337 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature