KMT2D preferentially binds mRNAs of the genes it regulates, suggesting a role in RNA processing.

ABSTRACT: Histone lysine methyltransferases (HKMTs) perform vital roles in cellular life by controlling gene expression programs through the posttranslational modification of histone tails. Since many of them are intimately involved in the development of different diseases, including several cancers, understanding the molecular mechanisms that control their target recognition and activity is vital for the treatment and prevention of such conditions. RNA binding has been shown to be an important regulatory factor in the function of several HKMTs, such as the yeast Set1 and the human Ezh2. Moreover, many HKMTs are capable of RNA binding in the absence of a canonical RNA binding domain. Here, we explored the RNA binding capacity of KMT2D, one of the major H3K4 monomethyl transferases in enhancers, usin

SUBMITTER: Amin HM 

PROVIDER: S-EPMC10731558 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature