Neuroblastoma is associated with alterations in gut microbiome composition subsequent to maternal microbial seeding.

ABSTRACT:

Background

Neuroblastoma is the most frequent extracranial solid tumour in children, accounting for ∼15% of deaths due to cancer in childhood. The most common clinical presentation are abdominal tumours. An altered gut microbiome composition has been linked to multiple cancer types, and reported in murine models of neuroblastoma. Whether children with neuroblastoma display alterations in gut microbiome composition remains unexplored.

Methods

We assessed gut microbiome composition by shotgun metagenomic profiling in an observational cross-sectional study on 288 individuals, consisting of patients with a diagnosis of neuroblastoma at disease onset (N = 63), healthy controls matching the patients on the main covariates of microbiome composition (N = 94), healthy siblings of the

SUBMITTER: Valles-Colomer M 

PROVIDER: S-EPMC10731604 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature