Toward ⁶⁸Ga and ⁶⁴Cu Positron Emission Tomography Probes: Is H₂dedpa-N,N'-pram the Missing Link for dedpa Conjugation?

ABSTRACT: H₂dedpa-N,N'-pram (H₂L¹), a new chelator derived from the hexadentate ligand 1,2-bis[[(6-carboxypyridin-2-yl)methyl]amino]ethane (H₂dedpa), which incorporates 3-propylamine chains anchored to the secondary amines of the ethylenediamine core of the latter, has emerged as a very promising scaffold for preparing ⁶⁸Ga- and ⁶⁴Cu-based positron emission tomography probes. This new platform is cost-effective and easy to prepare, and the two pendant primary amines make it versatile for the preparation of bifunctional chelators by conjugation and/or click chemistry. Reported herein, we have also included the related H₂dedpa-N,N'-prpta (H₂L²) platform as a simple structural

SUBMITTER: Pena-Bonhome C 

PROVIDER: S-EPMC10731644 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature