Equilibrium Thermodynamics of Macropa Complexes with Selected Metal Isotopes of Radiopharmaceutical Interest.

ABSTRACT: To pursue the design of in vivo stable chelating systems for radiometals, a concise and straightforward method toolbox was developed combining NMR, isothermal titration calorimetry (ITC), and europium time-resolved laser-induced fluorescence spectroscopy (Eu-TRLFS). For this purpose, the macropa chelator was chosen, and Lu³⁺, La³⁺, Pb²⁺, Ra²⁺, and Ba²⁺ were chosen as radiopharmaceutically relevant metal ions. They differ in charge (2+ and 3+) and coordination properties (main group vs lanthanides). ¹H NMR was used to determine four pK_a values (±0.15; carboxylate functions, 2.40 and 3.13; amino functions, 6.80 and 7.73). Eu-TRLFS was used to validate the exclusive existence of the 1:1 M^n+<

SUBMITTER: Blei MK 

PROVIDER: S-EPMC10731647 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature