Versatile Diphosphine Chelators for Radiolabeling Peptides with ^99mTc and ⁶⁴Cu.

ABSTRACT: We have developed a diphosphine (DP) platform for radiolabeling peptides with ^99mTc and ⁶⁴Cu for molecular SPECT and PET imaging, respectively. Two diphosphines, 2,3-bis(diphenylphosphino)maleic anhydride (DP^Ph) and 2,3-bis(di-p-tolylphosphino)maleic anhydride (DP^Tol), were each reacted with a Prostate Specific Membrane Antigen-targeted dipeptide (PSMAt) to yield the bioconjugates DP^Ph-PSMAt and DP^Tol-PSMAt, as well as an integrin-targeted cyclic peptide, RGD, to yield the bioconjugates DP^Ph-RGD and DP^Tol-RGD. Each of these DP-PSMAt conjugates formed geometric cis/trans-[MO₂(DP^X-PSMAt)₂]⁺ (M = ^99mTc, ^99gTc, ^nat</

SUBMITTER: Hungnes IN 

PROVIDER: S-EPMC10731650 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature